Doctor Esther Pearson is a medical examiner who works for the Chicago Police Department. She was involved in at least three homicide cases Detective Raymond Vecchio investigated in 1994 and 1995, those of Francis Calibri, Victoria Metcalf's former partner in crime Jolly Hughes and one of Doctor Martins' patients who had commited suicide after being given insufficiently tested medication produced by an influential pharmaceutical company.

Diefenbaker is quite fascinated by Doctor Pearson because of her blonde hair; Benton Fraser justifies this by saying that Northern Canada being mostly populated by Aboriginal people, blondes have always been a rare sight for the wolf.

Doctor Pearson and Lieutenant Harding Welsh attended a concert together in December of 1994.

Esther Pearson was portrayed by American actress Deborah Rennard.